What is a Polynucleotide Treatment?
Polynucleotides are highly purified chains of nucleic acids (the building blocks found in DNA/RNA). When injected into precise layers of the skin, they act as biostimulators—promoting cell renewal, improving hydration and supporting tissue remodelling. The result is skin that looks smoother, bouncier and more radiant, with improvements building over the weeks following treatment.
Who is this treatment for?
Polynucleotides are suited to anyone noticing early to moderate signs of ageing or textural change, or those seeking a preventative, regenerative approach. They’re especially popular for tired or crepey under-eyes, fine lines, uneven texture, and skin that has lost its glow.
Common treatment areas: face, tear trough/under-eye, neck, décolletage, and hands.
Benefits of Polynucleotide Treatments
Revives dull, dehydrated or crepey skin
Improves the look of fine lines and laxity
Supports collagen, elastin and skin regeneration
Gentle option for under-eye rejuvenation
Progressive, natural-looking results
Your Treatment Journey
Your experience begins with a medical consultation to assess suitability and your goals. On treatment day, we cleanse and apply a topical anaesthetic for comfort before delivering precise micro-injections of polynucleotides to targeted areas. The appointment typically takes 30–45 minutes, and you can return to normal activities soon after.
1 SESSION
Plinest Eye – £200
Newest – £200
Nucleofill – £150
Vitaran – £150
3 SESSIONS
(recommended for the best results)
Plinest Eye – £500
Newest – £500
Nucleofill – £400
Vitaran – £400
Operation Information
Procedure time
Usually 30 – 45 Minutes
Treatments Needed!
Usually 2-3 sessions are needed with 2-4 weeks in between
Recovery time
24–72 hours possible light marks/bumps
Discomfort level
Very mild
Anesthesia
Not required
Duration of results
Frequently Asked Questions (FAQs)
Are polynucleotides the same as skin boosters?
They’re part of the same family of injectable skin treatments but work more regeneratively. While classic boosters focus on hydration, polynucleotides also support repair and remodelling for texture and firmness.
How many sessions will I need?
Most clients benefit from 2–3 sessions initially, then maintenance every 6–9 months. Your practitioner will advise a bespoke plan.
Is it good for under-eyes?
Yes—polynucleotides are a popular choice to refresh the tear trough area, improving crepiness and brightness with minimal downtime.
Does it hurt?
Discomfort is usually mild. We apply topical anaesthetic and use refined techniques to keep you comfortable.
Are There any Side Effects To Polynucleotides?
Mild swelling and bruising are the most common potential side effects immediately following your treatment session. At The Skin, to Love Clinic you will only ever be treated by a medical professional with extensive experience and the skills to handle any possible side effects or complications.
Your practitioner will discuss any possible side effects, questions you may have about Profhilo and any aftercare you should adhere to prior to you having treatment.
Who isn’t suitable?
You should avoid treatment if pregnant or breastfeeding, if you have an active skin infection, or certain medical conditions. We’ll complete a full medical assessment at consultation.